从死体下垂体生长激素传递的粉样β蛋白病理
Silvia A Purro1, Mark A Farrow1, Jacqueline Linehan1
1MRC Prion Unit at UCL, UCL Institute of Prion Diseases, London, UK.
Nature
|December 15, 2018
概括
人体生长激素与克鲁茨菲尔特-雅各布病传播相关的批量也含有粉样β种子. 这项研究实验证实这些受污染的激素可以传播阿尔茨海默病的病理.
科学领域:
- 神经科学
- 神经病理学
- 传染性疾病
背景情况:
- 对克鲁茨菲尔德- 雅各布病 (CJD) 进行人体生长激素 (c- hGH) 治疗的个体显示出异常的粉样β (Aβ) 沉积物.
- 之前的观察表明c-hGH批量可能被子和Aβ种子污染,但因果关系仍未被证明.
研究的目的:
- 通过受污染的人体垂体生长激素 (c-hGH) 检查β-粉样蛋白 (Aβ) 病理的阳性传播潜力.
- 对存档的c-hGH批量进行生物化学分析,以检测Aβ种子的存在,并评估它们的种子潜力.
主要方法:
- 鉴定和分析了来自阳性CJD和Aβ病理的患者的存档c- hGH瓶.
- 生物化学试验量化了c-hGH样本中的Aβ40,Aβ42和tau蛋白.
- 在基因改造以表达人类粉样蛋白前体的小鼠中测试了分析的c-hGH材料种植Aβ病理的能力.
主要成果:
- 某些已存档的c-hGH批量中发现含有大量的Aβ40,Aβ42和tau蛋白.
- 在小鼠中注射这种c-hGH物质诱导了Aβ斑块和脑Aβ-粉样血管病变的形成.
- 这些发现实验证实了存档c-hGH中Aβ种子的存在.
结论:
- 这项研究提供了实验证据,支持通过受污染的c-hGH传播Aβ病理的假设.
- 这些发现对阿尔茨海默病的预防和治疗策略有重大影响.
- 医疗和外科手术程序的审查是有必要的,因为可能会有意外的Aβ种子传播.
相关概念视频
Hormones of the Pituitary Gland
10.4K
The small, pea-sized pituitary gland is located at the base of the brain. It is crucial in regulating various bodily functions, from growth to reproduction. The gland is divided into the anterior lobe and the posterior lobe. The secretory cell clusters in the pars distalis of the anterior pituitary lobe are controlled by hypothalamic regulators and synthesize six primary hormones.
The most abundantly secreted hormone from the anterior lobe is the growth hormone, which controls overall growth by...
The most abundantly secreted hormone from the anterior lobe is the growth hormone, which controls overall growth by...
10.4K
Hypothalamic-Pituitary Axis
66.1K
The response to stress—be it physical or psychological, acute or chronic—involves activation of the Hypothalamic-Pituitary-Adrenal (HPA) axis. The HPA axis is part of the neuroendocrine system because it involves both neuronal and hormonal communication. Its function is to regulate homeostatic systems—metabolic, cardiovascular, and immune—providing the necessary means to respond to a stressor.
66.1K
Amyloid Fibrils
11.9K
Amyloid fibrils are aggregates of misfolded proteins. Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils.
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining,...
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining,...
11.9K
Plant Hormones
27.5K
Plant hormones—or phytohormones—are chemical molecules that modulate one or more physiological processes of a plant. In animals, hormones are often produced in specific glands and circulated via the circulatory system. However, plants lack hormone-producing glands.
27.5K
Hormonal Regulation
48.1K
Hormones regulate a significant portion of digestion through activation of the neuroendocrine system. The neuroendocrine system of digestion contains many different hormones all with multiple functions that are both, directly and indirectly, involved in digestion.
48.1K
Hormonal Regulation
36.1K
The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.
36.1K


