无金属转移C-C多重键的化
Weiqiang Chen1, Johannes C L Walker1, Martin Oestreich1
1Institut für Chemie , Technische Universität Berlin , Strasse des 17. Juni 115 , 10623 Berlin , Germany.
Journal of the American Chemical Society
|December 15, 2018
概括
一种新的循环-1,4-基化合物可安全地为化反应提供化. 这种方法避免了危险的化气体,使各种化的合成成为可能.
科学领域:
- 有机化学
- 合成化学
背景情况:
- 气态化 (HI) 是一种有价值的化试剂,但处理起来很危险.
- 在现场生成HI的现有方法通常涉及复杂的程序或不稳定的前体.
研究的目的:
- 设计和合成一个稳定的,酸的替代品.
- 使用这种替代品开发安全高效的水氧化方案.
主要方法:
- 一个循环-1,4-二烯衍生物在格拉姆尺度上合成.
- 替代物在布伦斯特德酸催化下与各种和发生反应.
- 分析了反应产品和副产品.
主要成果:
- 循环-1,4-二烯基替代物有效地将化转移到C-C多重键.
- 在不需要自由酸或酸的情况下进行反应.
- 替代物分解成挥发性多和乙烯,简化了净化.
- 一系列的乙烯酸,包括以前无法获得的,用立体控制合成.
结论:
- 已开发出一种安全且实用的替代气态化.
- 这种方法可促进各种乙烯酸的立体控制合成.
- 开发的协议在处理有机合成的危险试剂方面取得了重大进展.
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