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Basophil Activation Test for Allergy Diagnosis
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抗生素过敏

Kimberly G Blumenthal1, Jonny G Peter2, Jason A Trubiano3

  • 1Division of Rheumatology, Allergy and Immunology, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.

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|December 19, 2018
PubMed
概括
此摘要是机器生成的。

许多抗生素反应被错误地标记为过敏,导致抗生素耐药性增加和不良反应. 大多数被标记为青素过敏的患者并不是真正的过敏,可以通过测试安全地取消标记.

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科学领域:

  • 免疫学
  • 药理学
  • 公共卫生

背景情况:

  • 抗生素通常会引起严重的免疫中介药物反应,包括过敏反应和皮肤不良反应.
  • 许多报告的抗生素"过敏"是错误的诊断,不耐受性或无关反应,
  • 错误的抗生素过敏标签导致使用更广泛的抗生素,增加不良事件和抗菌耐药性.

研究的目的:

  • 提供对抗生素过敏的全球概述.
  • 讨论抗生素过敏的流行病学,分类,机制和管理.
  • 突出不准确的青素过敏标签对公共卫生的影响.

主要方法:

  • 对抗生素过敏的最新文献的审查.
  • 对抗生素过敏的流行病学数据的分析.
  • 检查药物反应和不耐受性背后的机制.
  • 对抗生素过敏的诊断和管理策略的评估.

主要成果:

  • 在被标记为抗生素过敏,特别是青素过敏的患者中,很大一部分在适当评估后并不是真正的过敏.
  • 不准确的过敏标签导致抗生素选择不足,增加医疗保健成本,并导致抗菌素耐药性.
  • 有效的风险分层,测试和分级的药物挑战可以取消大多数疑似青素过敏的患者的标签.

结论:

  • 抗生素过敏标签是一个主要的公共卫生问题,
  • 删除非过敏性青素反应的患者的标签对于改善抗生素管理和减少耐药性至关重要.
  • 全球需要全面的管理策略来应对抗生素过敏标签带来的挑战.