年轻人心力衰竭
Jasper Tromp1,2,3, Michael R MacDonald4, Wan Ting Tay2
1University Medical Center Groningen, Department of Cardiology, the Netherlands (J.T., C.S.P.L.).
Circulation
|December 20, 2018
概括
心脏衰竭与保存的喷射分数 (HFpEF) 影响年轻的成年人,通常是由肥胖引起的. 尽管HFpEF患者比老年患者的生活质量更好,但与没有心力衰竭的患者相比,年轻人面临的结果明显较差.
科学领域:
- 心脏病学
- 老年学
- 公共卫生
背景情况:
- 在老年人中,通常会出现心力衰竭与保留射出分数 (HFpEF).
- 在年轻人群体中,HFpEF的特征和结果仍未得到充分研究.
- 这项研究研究了65岁以下的个体的HFpEF.
研究的目的:
- 在年轻患者群体中描述HFpEF.
- 在不同年龄段的HFpEF患者中比较临床和心声学特征,生活质量和结果.
- 将非常年轻的HFpEF患者与年龄和性别匹配的对照患者进行比较.
主要方法:
- 来自亚洲11个地区的1203名HFpEF患者 (排泄分数≥50%) 的预期招募.
- 分类为年龄组:非常年轻 (<55岁),年轻 (55-64岁),年长 (65-74岁) 和老年人 (≥75岁).
- 临床数据,心声学,生活质量和1年结果的比较;非常年轻的HFpEF与对照者的比较.
主要成果:
- 37% 的HFpEF患者年龄在65岁以下;这一群体中男性占优势,肥胖率较高 (36% 与16%),功能低下,心房动和高血压较少.
- 在非常年轻和老年HFpEF患者中,左心室填充压力和高的患病率相似.
- 非常年轻的HFpEF患者比老年HFpEF患者有更好的生活质量和更低的1年死亡/住院率 (7%),但死亡率比对照患者高3倍.
结论:
- 年轻的HFpEF患者表现出与老年患者相似的不良心脏重塑.
- 与没有心力衰竭的对照组相比,年轻人的HFpEF结果明显较差.
- 在年轻人中,肥胖被认为是HFpEF的主要潜在因素.
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