在复杂分子的合成中与碳中心激素结合
Spencer P Pitre1, Nicholas A Weires1, Larry E Overman1
1Department of Chemistry , University of California, Irvine , Irvine , California 92697-2025 , United States.
Journal of the American Chemical Society
|December 20, 2018
概括
激素断片合反应是合成复杂分子的关键. 现代方法可以产生温和的基因,推进天然产品合成和总合成策略.
科学领域:
- 有机化学
- 合成化学
背景情况:
- 激素断片合反应对于构建复杂的分子结构至关重要.
- 这些反应使分子子单元的战略连接成为可能.
研究的目的:
- 在合成中审查基片合的早期和现代应用.
- 强调最近在温和的基因生成中取得的进展.
主要方法:
- 对基片合反应的文献综述.
- 突出自然产品合成中的应用.
- 专注于激进分子的现代方法.
主要成果:
- 展示了极端断片的历史意义和演变.
- 展示了这些反应在合成复杂的天然产品中的实用性.
- 展示了轻微激素生成技术对合成策略的影响.
结论:
- 在现代有机合成中, 基碎合是不可或缺的工具.
- 轻微基生成的进展正在扩大它们在总合成中的适用性.
- 本视角提供了关于激进合方法的发展和未来的见解.
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