热应激通过肌性状态诱导糖溶性色脂肪的形成
Yong Chen1,2,3,4, Kenji Ikeda1,2,3, Takeshi Yoneshiro1,2,3
1UCSF Diabetes Center, San Francisco, CA, USA.
Nature
|December 21, 2018
概括
研究人员发现了一种新型的色脂肪, 这一发现揭示了细胞可塑性和能量调节的新机制.
科学领域:
- 细胞可塑性和适应性
- 代谢调节
- 热生成
背景情况:
- 环境信号驱动细胞可塑性, 影响肌肉纤维类型和脂肪细胞发育等功能.
- 将生理刺激与发育可塑性联系在一起的分子机制尚未完全理解.
- 寒冷适应通常涉及色脂肪细胞生物生成的β-上腺体信号.
研究的目的:
- 研究一种新型的色脂肪细胞,
- 阐明调节这种独特的色脂肪亚型的分子机制.
- 了解它在能量稳定和生存中的作用.
主要方法:
- 一种新的色脂肪细胞亚型的特征.
- 对热应激的基因调节的分析.
- 关键调节蛋白的鉴定,包括GA结合蛋白α.
- 研究发育起源和信号通路.
主要成果:
- 鉴定出一种独特的白色脂肪细胞群,称为糖溶性白色脂肪,功能没有β-上腺素信号.
- 这种糖溶性色脂肪表现出增强的葡萄糖氧化.
- 鉴定出GA结合蛋白α是通过肌性中间体对其分化的关键调节剂.
- 证明了一个非正规的适应性热生成途径.
结论:
- 糖溶性色脂肪是一种独特的适应机制,
- 这种途径突出显示了由热应力诱导的原始细胞可塑性.
- 揭示了一个新的细胞成分, 对于能量稳定和生存至关重要.
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