在高风险患者中进行过导管大动脉置换后的五年临床结果和门耐用性
Romain Didier1, Hélène Eltchaninoff2, Patrick Donzeau-Gouge3
1Department of Cardiology, Brest University Hospital, France (R.D., M.G.).
Circulation
|December 21, 2018
概括
在高风险患者中,透过导管的动脉置换显示持续有效期长达5年. 植入后的临床事件很低,结构的恶化率也可以控制.
科学领域:
- 心脏病学
- 干预心脏病学
- 医疗器械
背景情况:
- 此前,FRANCE-2注册表已经证明过导管大动脉置换 (TAVR) 的早期和中期疗效.
- 本研究介绍了来自FRANCE-2注册表的5年后续结果.
研究的目的:
- 评估TAVR在5年后的长期临床和心声结果.
- 评估TAVR后的死亡率,临床事件和结构恶化 (SVD).
主要方法:
- 法国连续接受TAVR重症大动脉狭窄治疗的患者的分析.
- 在30天,6个月和每年长达5年的标准化随访.
- 根据Valve学术研究联盟的标准定义的临床事件;欧洲共识的SVD.
主要成果:
- 在4201名患者中,有95. 5%的患者有5年生命状态;所有原因的死亡率为60. 8%.
- 大多数心血管事件发生在第一个月内;心力衰竭发病率在第一年后降至每年< 5%.
- 严重和中度/严重SVD的5年率分别为2. 5%和13. 3%;严重SVD的死亡率没有显著差异.
结论:
- 在FRANCE-2注册中提供了对高风险人群的最大的5年数据集.
- 低临床事件率和1年后的SVD支持TAVR对两种假肢类型的长期疗效.
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