总合成的 (-) - 无二. 一个跨环的方法
Zhanchao Meng1, Alois Fürstner1
1Max-Planck-Institut für Kohlenforschung , 45470 Mülheim/Ruhr , Germany.
Journal of the American Chemical Society
|December 22, 2018
概括
研究人员合成了一种具有独特的九个环形结构的复杂分子, 这是通过一种新级反应序列实现的,该序列涉及多个合成步骤和转换.
科学领域:
- 有机化学
- 自然产品合成
- 合成方法
背景情况:
- 海洋天然产物,如状化物,通常具有具有显著生物活性的复杂结构.
- 开发高效的合成途径来获取这些复杂的分子对于进一步的生物研究和潜在的药物发现至关重要.
研究的目的:
- 为了合成诺-核化物三环骨架.
- 探索一种用于构建复杂分子结构的新级反应序列.
主要方法:
- 通过环闭基转化制备一个宏环前体.
- 随后的转水化/碳化,以使宏观循环功能化.
- 一系列的反应包括跨环迈克尔反应,碳酸盐排放和布化物形成.
- 自发的Oxa-Michael添加甲醇提供最终产品.
主要成果:
- 成功合成了具有挑战性的三环环状化物结构.
- 展示复杂分子组合的高效级联反应序列.
- 在三环框架内形成九个环连接.
结论:
- 开发的合成策略为构建复杂的多循环天然产品提供了强大的方法.
- 级联反应序列提供了一个简洁而有效的途径,使得状化物和相关化合物.
- 这项工作扩大了在海洋天然产品中发现的复杂分子支架的合成工具包.
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