循环细胞因子和中风风险的基因决定水平
Marios K Georgakis1,2, Dipender Gill3, Kristiina Rannikmäe4
1Institute for Stroke and Dementia Research, University Hospital of Ludwig-Maximilians-University, Munich, Germany (M.K.G., J.B., R.M., M.D.).
Circulation
|December 28, 2018
概括
基因上较高的单细胞化学吸引蛋白-1 (MCP-1) 会增加中风风险,特别是大动脉和心血管中风. 需要进一步的研究来确定MCP-1是否可以预防中风.
科学领域:
- 心血管遗传学
- 中风病因
- 炎症生物标志物
背景情况:
- 细胞因子和生长因子与血管疾病的发展有关.
- 观察性研究表明循环细胞因子/生长因子水平与中风风险之间存在联系.
- 这些因子在中风中所起的作用需要进一步研究.
研究的目的:
- 研究基因决定的细胞因子和生长因子循环水平与中风风险及其病因亚型之间的关联.
- 使用两个样本的门德尔随机化方法来评估因果关系.
主要方法:
- 使用全基因组关联研究数据进行了双样本的门德尔随机化研究.
- 对41种细胞因子和生长因子的遗传仪器来自大量的健康成年人群.
- 在MEGASTROKE数据集中评估了与中风和中风亚型的相关性,并在英国生物库中验证.
主要成果:
- 对单细胞化学吸引蛋白-1 (MCP-1/ CCL2) 水平较高的遗传倾向与任何中风,任何缺血性中风,大动脉中风和心血管中风的风险增加有关.
- 在小血管中风或脑内出血方面没有发现显著的关联.
- 升高的MCP-1水平也与冠状动脉疾病和心肌梗塞有关,但与心房动无关.
结论:
- 基因决定的MCP-1水平升高与中风的风险增加有关,特别是大动脉和心血管血栓亚型.
- 这些发现表明MCP-1在中风发病过程中的潜在因果作用.
- 需要进一步的研究来探索针对MCP-1或其受体的治疗策略以预防中风.
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