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Updated: Jan 31, 2026

Molecular Analysis of Endothelial-mesenchymal Transition Induced by Transforming Growth Factor-β Signaling
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Published on: August 3, 2018

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LMO7 是转化生长因子β信号和纤维化的负反调节剂

Yi Xie1,2, Allison C Ostriker1,2, Yu Jin1,2

  • 1Departments of Medicine (Cardiovascular Medicine) (Y.X., A.C.O., Y.J., K.A.M., J.H.), Yale University, New Haven, CT.

Circulation
|December 28, 2018
PubMed
概括

通过负调节转化生长因子β (TGF-β) 信号传递,只有LIM域7 (LMO7) 限制了血管纤维化. 在血管损伤后,LMO7的损失会放大TGF-β的反应,促进新生体的形成和纤维化.

关键词:
细胞外基质纤维化滑动肌肉转录因子转化增长因子

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