随机IABP-SHOCK II试验的长期6年结果
在PubMed上查看摘要
概括
此摘要是机器生成的。对于心脏病发作后心脏性休克患者来说,内气球逆脉冲 (IABP) 没有改善长期存活率. 死亡率仍然很高, 尽管IABP和再血管治疗.
科学领域
- 心脏病学
- 临床试验
- 医疗器械
背景情况
- 在心脏性休克中,内气球逆脉冲 (IABP) 的作用仍在争论中,之前的试验得出了中立的结果.
- 对IABP对急性心肌梗塞并发症的临床结果的长期影响的随机数据有限.
- 对接受同时治疗的心脏性休克患者的一般长期结果的证据很少.
研究的目的
- 评估IABP对所有原因死亡的长期 (6年) 影响,这些患者患有心脏性休克并发症急性心肌梗塞.
- 评估IABP对复发性心肌梗塞,中风,重复血管化和心脏再住院的影响.
- 用IABP治疗的幸存者的生活质量与对照组中的患者进行比较.
主要方法
- 这项研究使用了多中心,随机,开放的IABP- SHOCK II试验的数据.
- 在2009年至2012年间,有600名患有心脏性休克并发症急性心肌梗塞的患者经历了早期再血管化.
- 随机化后长期随访的中位数为6. 2年.
主要成果
- 在6年随访后,IABP组 (66. 3%) 和对照组 (67. 0%) 之间没有发现任何原因死亡率的显著差异 (RR 0. 99;P=0. 98).
- 在两组之间,复发性心肌梗塞,中风,重复血管化和心脏再住院的发生率相似 (所有P>0.05).
- 通过EuroQol 5D和NYHA等级评估的幸存者的生活质量在IABP和对照组之间没有差异.
结论
- 在心脏性休克患者的6年长期随访中,心脏气球逆脉冲 (IABP) 不影响所有原因的死亡率.
- 即使同时进行了再血管治疗,心脏性休克患者的死亡率仍然很高 (三分之二).
- 在这种患者群体中,IABP对长期临床结果没有明显的益处.
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