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Updated: Jan 31, 2026

A High-Throughput Luciferase Assay to Evaluate Proteolysis of the Single-Turnover Protease PCSK9
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A High-Throughput Luciferase Assay to Evaluate Proteolysis of the Single-Turnover Protease PCSK9

Published on: August 28, 2018

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脂蛋白 (a),PCSK9抑制和心血管风险

Michelle L O'Donoghue1, Sergio Fazio2, Robert P Giugliano1

  • 1TIMI Study Group, Cardiovascular Division, Brigham and Women's Hospital, Boston, MA (M.L.O., R.P.G., E.K., K.A.I., M.S.S.).

Circulation
|December 28, 2018
PubMed
概括

较高的脂蛋白水平会增加心血管风险. 作为PCSK9抑制剂的Evolocumab有效降低Lp(a) 的水平,并且在基线Lp(a) 升高的患者中提供更大的冠状动脉益处.

关键词:
动脉样硬化临床试验脂肪蛋白 (a)

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