短链脂肪酸 propionate 防止高血压心血管损伤
Hendrik Bartolomaeus1,2,3,4,5, András Balogh1,2,3,4,5, Mina Yakoub6
1Experimental and Clinical Research Center, a Cooperation of Charité-Universitätsmedizin Berlin and Max Delbruck Center for Molecular Medicine, Germany (H.B., A.B., L.M., D.T., S.W., E.G.A., N.H., K.K., J.F., M.G., R.D., S.K.F., D.N.M., N.W.).
Circulation
|December 28, 2018
概括
短链脂肪酸 (SCFA) 通过调节T细胞反应,可以防止高血压和心血管损伤. 增加SCFA生产的饮食修改可能为心血管疾病提供非药物预防策略.
科学领域:
- 心血管科学
- 免疫学
- 微生物组研究
背景情况:
- 动脉高血压及其后果涉及T细胞介导的炎症.
- 实验性抗炎疗法在缓解高血压末端器官损伤方面表现有前途.
- 来自肠道微生物群的短链脂肪酸 (SCFA) 影响免疫平衡和心血管健康.
研究的目的:
- 在小鼠模型中研究SCFA酸对高血压心脏损伤和动脉样硬化的作用.
- 为了阐明酸盐心脏保护作用的免疫调节机制.
主要方法:
- 在饮用水中给野生型NMRI和非脂蛋白E淘汰小鼠注射酸盐或对照剂.
- 在两种小鼠模型中使用血管素II输液诱导高血压.
- 使用组织学,心声学,流细胞计和免疫光学评估心脏损伤,动脉样硬化和免疫细胞概况.
主要成果:
- 氨酸减弱了心脏缩,纤维化,血管功能障碍和高血压.
- 降低了对心律失常的敏感性,并减少了大动脉动脉样损伤面积.
- 通过减少特异性T细胞群和局部心脏免疫细胞透来减轻系统性炎症.
- 心脏保护作用依赖于调节性T细胞.
结论:
- 与酸一样,SCFA具有有益于心血管健康的免疫调节特性.
- 通过改变生活方式增加SCFA可以作为高血压心血管疾病的非药物预防策略.
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