在心力衰竭中使用流感疫苗
Daniel Modin1, Mads Emil Jørgensen1, Gunnar Gislason1,2
1Department of Cardiology, Herlev & Gentofte Hospital (D.M., M.E.J., G.G., J.S.J., C.T.-P, T.B.-S.), University of Copenhagen, Denmark.
Circulation
|December 28, 2018
概括
接种流感疫苗可显著降低心力衰竭患者的死亡风险. 与间歇性或晚期疫苗接种相比,每年和早期的疫苗接种提供了更大的生存益处.
科学领域:
- 心脏病学
- 传染性疾病
- 公共卫生
背景情况:
- 流感对心力衰竭患者构成重大风险.
- 关于流感疫苗对HF患者结果的影响的数据有限.
- 本研究研究了新诊断的HF患者的流感疫苗接种与长期存活之间的关联.
研究的目的:
- 确定流感疫苗是否能改善新诊断的心力衰竭患者的长期存活率.
- 分析疫苗接种频率和时间对HF患者死亡风险的影响.
主要方法:
- 在2003年至2015年期间诊断出HF的134,048名丹麦患者的全国性队列研究.
- 用于跟踪疫苗接种情况和结果的全国性登记数据.
- 时间依赖的考克斯回归分析对多个混因素进行了调整.
主要成果:
- 流感疫苗接种与所有原因和心血管死亡的风险降低了18%.
- 年度和早期 (九月至十月) 疫苗接种显示出较大的死亡率降低.
- 与间歇性疫苗接种相比,频繁的疫苗接种与更大的生存益处相关.
结论:
- 流感疫苗接种与心力衰竭患者的死亡率降低有关.
- 频繁和早期的流感疫苗接种策略可以提高存活率.
- 这些发现支持常规流感疫苗接种心力衰竭患者.
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