内皮C型尿酸是血管生成和血管重塑的关键调节剂
在PubMed上查看摘要
概括
此摘要是机器生成的。C型尿酸 (CNP) 对于缺血后的血管修复至关重要. 激活其受体NPR-C促进血管生成和血管重塑, 为心血管疾病提供新的治疗策略.
科学领域
- 心血管生物学
- 内皮细胞生物学
- 分子医学
背景情况
- 血管新生和血管重塑是对缺血性心血管事件的重要先天反应.
- 内皮在恢复血液供应和氧化方面发挥着至关重要的作用.
- C型尿酸 (CNP) 是调节血管平衡的关键内皮信号分子.
研究的目的
- 调查 CNP 在血管生成和血管改造中所起的核心作用.
- 在内皮细胞和体内模型中探索CNP及其受体的功能.
- 在患有外周动脉疾病的患者中检查 CNP/ NPR- C 表达.
主要方法
- 在实验室中使用来自各种淘汰小鼠的内皮细胞和大动脉环.
- 在缺血或血管损伤后对新血管和血管重塑的体内评估.
- 在患者组织中分析CNP和NPR-C表达.
主要成果
- 降低的CNP和NPR- C水平与临床血管缺血有关.
- 抑制CNP或NPR-C会损害体外和体内血管生成和重塑.
- CNP/NPR-C的益血管性作用涉及Gi,ERK1/2和PI3Kγ/Akt的信号通路.
- 在CNP缺乏的模型中,药理性CNP的使用挽救了受损的血管生成.
结论
- CNP在缺血诱导的血管生成和血管重塑中起着核心的病理生理作用.
- 对于外周动脉疾病和缺血性疾病来说,NPR-C激活是潜在的治疗点.
相关概念视频
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits. Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
Nucleosomes are the basic units of chromatin compaction. Each nucleosome consists of the DNA bound tightly around a histone core, which makes the DNA inaccessible to DNA binding proteins such as DNA polymerase and RNA polymerase. Hence, the fundamental problem is to ensure access to DNA when appropriate, despite the compact and protective chromatin structure.
Nucleosome remodeling complex
Eukaryotic cells have specialized enzymes called ATP-dependent nucleosome remodeling enzymes. These enzymes...
Hormones can be classified into three main types based on their chemical structures: steroids, peptides, and amines. Their actions are mediated by the specific receptors they bind to on target cells.
Steroid hormones are derived from cholesterol and are lipophilic in nature. This allows them to readily traverse the lipid-rich cell membrane to bind to their intracellular receptors in the cytoplasm or nucleus. Once bound, the cytoplasmic hormone-receptor complex translocates to the nucleus....
A peptide bond covalently attaches amino acids through a dehydration reaction. One amino acid's carboxyl group and another amino acid's amino group combine, releasing a water molecule. The resulting bond is the peptide bond. The products that such linkages form are peptides. As more amino acids join this growing chain, the resulting chain is a polypeptide. Each polypeptide has a free amino group at one end. This end has the N-terminal, or the amino-terminal, and the other end has a free...
It is vital to regulate the activity of enzymatic as well as non-enzymatic proteins inside the cell. This can be achieved either through creating a balance between their rate of synthesis and degradation or regulating the intrinsic activity of the protein. Both these regulation mechanisms play an essential role in the normal functioning of cells.
Protein degradation plays two important roles in the cells. It helps to protect cells from misfolded or damaged proteins before they lead to a...

