睡眠呼吸暂停与黑人血压控制之间的联系
Dayna A Johnson1,2,3, S Justin Thomas4, Marwah Abdalla5
1Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA (D.A.J., N.G., M.R., S.R.).
Circulation
|December 28, 2018
概括
未经治疗的中度或重度阻塞性睡眠呼吸暂停 (OSA) 会显著增加黑人成年人患高血压的几率. 这表明OSA可能是该群体血压失控的关键因素.
科学领域:
- 心脏病学
- 睡眠医学
- 公共卫生
背景情况:
- 黑人成年人患高血压和失控血压的比例很高.
- 未经治疗的睡眠呼吸暂停是这一群体高血压的潜在因素.
研究的目的:
- 在黑人中研究睡眠呼吸暂停与失控血压 (BP) 和抗高血压之间的联系.
主要方法:
- 使用了来自杰克逊心脏睡眠研究 (N=913) 的数据,以及家庭睡眠呼吸暂停研究和临床血压测量.
- 通过呼吸事件指数定义的中度/ 严重阻塞性睡眠呼吸暂停 (OSA) ≥15和夜间低氧化症的% 睡眠时间与< 90% 氧血球和.
- 使用多项逻辑回归来分析多变量调整后的关联.
主要成果:
- 在高血压患者中 (N=664),有25.7%的患者患有OSA,其中94%未接受治疗. 48% 的患者患有无法控制的高血压,14% 的患者患有抗性高血压.
- 中度或重度的OSA与耐药性高血压的几率高出2. 0倍 (95% CI,1. 14-3. 67).
- 晚间低氧症的每次SD增加与耐药性高血压的概率比率为1. 25 (95% CI,1. 01-1.55). OSA与不受控制的血压没有关联.
结论:
- 没有治疗的中度或重度OSA与黑人成年人抗性高血压的可能性显著增加.
- 结果表明未经治疗的OSA可能在该人群中发挥不充分的血压控制作用.
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