相关实验视频

Updated: Jan 31, 2026

Combined DNA-RNA Fluorescent In situ Hybridization FISH to Study X Chromosome Inactivation in Differentiated Female Mouse Embryonic Stem Cells
15:54

Combined DNA-RNA Fluorescent In situ Hybridization FISH to Study X Chromosome Inactivation in Differentiated Female Mouse Embryonic Stem Cells

Published on: June 14, 2014

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早期染色体变化与X染色体不活化的关系

Jan Jakub Żylicz1, Aurélie Bousard2, Kristina Žumer3

  • 1Institut Curie, PSL Research University, CNRS UMR3215, INSERM U934, UPMC Paris-Sorbonne, 75005 Paris, France; University of Cambridge, Department of Physiology, Development and Neuroscience, Cambridge CB2 3EG, UK.

Cell
|January 1, 2019
PubMed
概括

这项研究揭示了X染色体无活化 (XCI) 期间最早的染色质变化,确定了基因组脱乙烯化和H2AK119无化作为关键事件. 这些涉及HDAC3和PRC1的修改对于启动女性细胞的基因沉默至关重要.

关键词:
在中国中华人民共和国聚合器X 染色体的不活化一个胚胎干细胞表观遗传学基因组乙化基因组脱乙酶

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