高酸饮食诱导运动不耐受,并损害小鼠的脂肪酸代谢
Poghni Peri-Okonny1, Kedryn K Baskin2,3, Gary Iwamoto4
1Department of Internal Medicine, Hypertension Section (P.P.-O., H.K.K., W.V.), University of Texas Southwestern Medical Center, Dallas.
Circulation
|January 8, 2019
概括
饮食中的高无机酸盐 (Pi) 与体力活动和运动能力的降低有关. 这项研究显示Pi过量会对骨肌肉和运动表现产生负面影响,
科学领域:
- 营养科学
- 心血管生理学
- 骨肌肉新陈代谢
背景情况:
- 无机酸盐 (Pi) 在西方饮食中被广泛用作防腐剂和增味剂.
- 身体不活动在西方社会普遍存在, 与心血管风险增加有关.
- 饮食中的Pi过量对运动不耐受和身体不活动的作用尚不清楚.
研究的目的:
- 研究无机酸盐 (Pi) 含量与人类体力活动之间的关联.
- 在动物模型中确定饮食中的Pi对运动能力和骨肌肉代谢的直接影响.
- 探索Pi对肌肉细胞脂肪酸代谢相关的基因表达的影响.
主要方法:
- 人类研究 (达拉斯心脏研究第二阶段) 通过动图评估血清Pi,通过核磁共振测试评估身体活动,通过核磁共振测试评估心脏功能.
- 动物研究 (C57/BL6小鼠) 评估了高Pi与正常Pi饮食中的运动能力和代谢标志物.
- 在体外研究中使用C2C12神经管暴露于不同Pi度以评估肌肉代谢.
主要成果:
- 人类血清Pi值较高与中度至强度体力活动减少和久坐时间增加相关.
- 在小鼠中,高Pi饮食降低了最大的氧气吸收,运动持续时间,自发活动和脂肪氧化.
- 在动物和实验室模型中,Pi 过量降低了参与肌肉脂肪酸代谢的关键基因.
结论:
- 饮食中的Pi过量会对骨肌肉脂肪酸代谢和运动能力产生不利影响.
- 这些影响与肥胖和心脏功能无关.
- 饮食Pi代表了对抗与西方饮食相关的身体不活动的潜在可修改目标.
更多相关视频
06:28A Chronic High-Intensity Interval Training and Diet-Induced Obesity Model to Maximize Exercise Effort and Induce Physiologic Changes in Rats
Published on: April 28, 2023
1.4K
11:14Fatty Acid 13C Isotopologue Profiling Provides Insight into Trophic Carbon Transfer and Lipid Metabolism of Invertebrate Consumers
Published on: April 17, 2018
8.5K
相关概念视频
Overview of Fatty Acid Metabolism
36.9K
Lipids also are sources of energy that power cellular processes. Like carbohydrates, lipids are composed of carbon, hydrogen, and oxygen, but these atoms are arranged differently. Most lipids are nonpolar and hydrophobic. Major types include fats and oils, waxes, phospholipids, and steroids.
Fatty acids are catabolized in a process called beta-oxidation, which takes place in the matrix of the mitochondria and converts their fatty acid chains into two-carbon units of acetyl groups. The acetyl...
Fatty acids are catabolized in a process called beta-oxidation, which takes place in the matrix of the mitochondria and converts their fatty acid chains into two-carbon units of acetyl groups. The acetyl...
36.9K
What is Metabolism?
131.7K
Overview
131.7K
Phosphate Buffer
5.1K
The phosphate buffer system is a critical biological mechanism for maintaining pH stability in the body. This system operates primarily through two components: sodium dihydrogen phosphate (NaH2PO4), which acts as a weak acid, and sodium hydrogen phosphate (Na2HPO4), which serves as a weak base.
Sodium dihydrogen phosphate does not fully dissociate in neutral or acidic solutions. When a strong base, such as sodium hydroxide (NaOH), is introduced into the solution, sodium dihydrogen phosphate...
Sodium dihydrogen phosphate does not fully dissociate in neutral or acidic solutions. When a strong base, such as sodium hydroxide (NaOH), is introduced into the solution, sodium dihydrogen phosphate...
5.1K
Nucleic Acids
50.2K
Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes,...
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes,...
50.2K
Nucleic acids
189.6K
Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes,...
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes,...
189.6K
Exercise Stress Test
1.3K
Introduction
Exercise stress testing, commonly known as a treadmill test, is a noninvasive procedure used to evaluate cardiovascular function and diagnose heart conditions.
Definition
An exercise stress test measures the heart's response to exertion using a treadmill or stationary bicycle. Chest electrodes record the heart's electrical activity through an ECG, and blood pressure is monitored regularly.
Purposes
Exercise stress testing, commonly known as a treadmill test, is a noninvasive procedure used to evaluate cardiovascular function and diagnose heart conditions.
Definition
An exercise stress test measures the heart's response to exertion using a treadmill or stationary bicycle. Chest electrodes record the heart's electrical activity through an ECG, and blood pressure is monitored regularly.
Purposes
1.3K
