再循环的肠道IgA产生细胞通过IL-10调节神经炎症
Olga L Rojas1, Anne-Katrin Pröbstel2, Elisa A Porfilio1
1Department of Immunology, University of Toronto, Toronto, ON M5S 1A8, Canada.
Cell
|January 8, 2019
概括
在多发性硬化症 (MS) 模型中,产生肠道免疫球蛋白A (IgA) 的血细胞 (PCs) 抑制神经炎症. 肠道IgA+PC降低与疾病严重程度相关,突出显示了它们的意外保护作用.
科学领域:
- 神经免疫学
- 微生物组与免疫系统的相互作用
- 自身免疫性疾病
背景情况:
- 在多发性硬化症患者的中枢神经系统 (CNS) 中观察到血细胞 (PCs),但它们的起源和功能仍然难以捉摸.
- 人们越来越认识到肠道微生物对中枢神经系统自身免疫的影响,但具体的细胞机制尚未完全理解.
研究的目的:
- 在实验性自身免疫脑膜炎 (EAE) 期间,研究免疫球蛋白A (IgA) 生产中枢神经系统血细胞 (PCs) 的起源和作用,这是MS的一个模型.
- 为了确定肠道衍生IgA+PC是否会影响神经炎症的过程.
主要方法:
- 在小鼠EAE模型中追踪中枢神经系统血细胞的起源.
- 在肠道和中枢神经系统中量化IgA+血细胞和IgA结合的细菌.
- 操纵血细胞 (PB) 和PC群体并评估EAE的严重程度.
- 评估介于IgA+ PB/PC的抗药性中的IL-10的作用.
主要成果:
- 在EAE小鼠中,中枢神经系统PC的一个子集来自肠道并产生IgA.
- 在EAE和MS复发期间,肠道IgA+PC和IgA结合的便细菌都减少.
- PBs/PCs的耗尽加剧了EAE,通过引入来自肠道的IgA+PCs来逆转.
- 过多的IgA+PBs/PCs会导致对EAE的耐药性,这取决于IL-10的表达.
结论:
- 在抑制神经炎症方面,来自肠道的IgA+等离子体和等离子体细胞起着至关重要的,意想不到的作用.
- 来自肠道的IgA+PCs的调动代表了对MS的潜在治疗途径.
- 由IgA+PBs/PCs产生的互白素10对于在EAE中产生抗神经炎症至关重要.
更多相关视频
16:04A Tetracycline-regulated Cell Line Produces High-titer Lentiviral Vectors that Specifically Target Dendritic Cells
Published on: June 19, 2013
15.1K
14:18Author Spotlight: Investigating the Potential of Chinese Herbal Medicinal Active Dioscin in Treating IgA Nephropathy
Published on: October 13, 2023
1.8K
相关概念视频
pH Regulation in Cells
7.6K
pH plays a critical role in maintaining normal cellular activities. It helps maintain the structure and function of various proteins, dictates the charge on cellular membranes, and is crucial for metabolic reactions inside the cell. Moreover, cells use the energy from the proton motive force to generate ATP.
Cytosolic pH
Under physiological conditions, the cytosolic pH is slightly more acidic than the extracellular pH. However, cells must prevent further acidification of their cytosol to...
Cytosolic pH
Under physiological conditions, the cytosolic pH is slightly more acidic than the extracellular pH. However, cells must prevent further acidification of their cytosol to...
7.6K
Anatomy of the Intestines
87.4K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
87.4K
Neural Regulation
43.3K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
43.3K
Renewal of Intestinal Stem Cells
3.2K
The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the...
3.2K
Epigenetic Regulation
33.7K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
33.7K
Regulated mRNA Transport
7.0K
In eukaryotes, transcription and translation are compartmentalized; an mRNA is first synthesized in the nucleus and then selectively transported to the cytoplasm for protein synthesis. Before transport, a pre-mRNA undergoes several steps of post-transcriptional modifications including splicing, 5' capping, and the addition of a poly-adenine tail. Various proteins bind to the pre-mRNA during these modifications. The mRNA transport takes place with the help of multiple proteins playing...
7.0K
