与素和素键直接比较的离子传输
Lucia M Lee1, Maria Tsemperouli1, Amalia I Poblador-Bahamonde1
1School of Chemistry and Biochemistry, NCCR Chemical Biology , University of Geneva , CH-1211 Geneva , Switzerland.
Journal of the American Chemical Society
|January 9, 2019
概括
与基因和基因键相比,基因键表现出优越的跨膜离子传输. 双基烯酸作为有效的载体,表现出高选择性并避免膜破坏.
科学领域:
- 超分子化学
- 膜运输
- 素结合
背景情况:
- 通过脂质双层的阳离子运输对生物过程至关重要.
- 聚基,基和基键是具有分子识别和运输潜力的非共价相互作用.
- 开发选择性和高效的离子载体是超分子化学的一个关键挑战.
研究的目的:
- 引入和研究通过基因结合化合物介导的跨膜离子传输.
- 为了比较pnictogen-bonding载体与它们的 chalcogen-和 halogen-bonding对应物的疗效和特性.
- 阐明控制离子传输效率和选择性的结构和电子因素.
主要方法:
- 聚基结合 (以反为中心) 和基结合 (以为中心) 化合物的合成和表征.
- 电生理学研究以测量跨膜离子电流和单通道特征.
- 染料泄漏测试以评估膜破坏情况.
- 使用不同离子和离子的选择性研究.
主要成果:
- 聚基结合化合物 (甲) 呈现出"过强"的离子结合,导致膜破坏和不规则的电流.
- 碳素结合化合物 (双甲) 具有高纳米分子活性和高选择性 (例如,PCl/Na=10.4).
- 结合化合物 (以为中心) 的活性明显较低 (3级较低).
- 由于膜干扰,基因结合载体的选择性较低.
结论:
- 基键,特别是在双甲基中,对于跨膜离子传输非常有效.
- 基结合系统的二维结构,定向性,疏水性和阴离子-π 相互作用有助于它们的卓越性能.
- 与基因键相比,基因键不太适合有效且无破坏性的离子传输.
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