移动PEAR转录因子将位置线索整合到主要变骨生长
Shunsuke Miyashima1,2, Pawel Roszak1,3, Iris Sevilem1
1Institute of Biotechnology, HiLIFE/Organismal and Evolutionary Biology Research Programme, Faculty of Biological and Environmental Sciences, Viikki Plant Science Centre, University of Helsinki, Helsinki, Finland.
Nature
|January 11, 2019
概括
植物的辐射生长是由PEAR蛋白组织的,它们激活生长基因并与HD-ZIP III蛋白形成边界. 这个网络将激素和miRNA信号整合到根部发育中.
科学领域:
- 植物生物学
- 发育生物学
- 遗传学
背景情况:
- 植物的辐射生长对发育至关重要,但对其调节的了解很少.
- 这一过程涉及到前进细胞的早期原始化和随后的血管变异细胞的激活.
- 它与动物系统的发育模式有相似之处.
研究的目的:
- 阐明组织Arabidopsis根的辐射生长启动的分子机制.
- 确定参与细胞分裂和生长边界的关键调节者.
主要方法:
- 研究了Arabidopsis根前组织中的基因表达模式.
- 分析了PHLOEM EARLY DOF (PEAR) 蛋白和HD-ZIP III转录因子的功能.
- 研究了细胞激素,auxin和microRNAs (miR165/166) 在调节基因表达中的作用.
主要成果:
- 细胞因素信号诱导原体元素中的PEAR蛋白 (PEAR1,PEAR2,DOF6,TMO6,OBP2,HCA2).
- 皮尔蛋白形成了一个激活辐射生长基因的梯度.
- 由auxin和miRNAs调节的HD-ZIP III蛋白质对抗PEAR蛋白质,从而形成一个反循环和分裂边界.
结论:
- 一个涉及PEAR和HD-ZIP III转录因子的调控网络控制了根径增长.
- 这个网络整合了空间激素和miRNA信息,以建立相邻的分裂和静止细胞区域.
- 这种机制为植物的持续辐射生长提供了基础.
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