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A Micropatterning Assay for Measuring Cell Chirality
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在宏循环基基因中螺旋性稳定性的机械稳定
Kevin J Weiland1, Thomas Brandl1, Kenneth Atz1
1Department of Chemistry , University of Basel , St. Johanns-Ring 19 , 4056 Basel , Switzerland.
Journal of the American Chemical Society
|January 12, 2019
概括
研究人员在宏观循环中使用Achiral paracyclophane稳定螺旋结构. 这种设计允许分离等离子体,为奇拉化学提供了新的可能性.
科学领域:
- 有机化学
- 超分子化学
- 基质材料
背景情况:
- 通过特定的设计原则,可以将Achiral分子转化为 chiral 结构.
- 宏观循环系统为控制分子结构和属性提供了独特的平台.
- 替代的 [2.2] 旋单元可以引入显著的三维扰动.
研究的目的:
- 开发一种设计原理,以稳定从非螺旋前体的螺旋性结构.
- 创建一个包含 [2.2] paracyclophane 单元的新型宏循环 oligothiophene.
- 为了实现合成螺旋性宏循环的反体分离.
主要方法:
- 将一个阿基拉四基替代的 [2.2] 基基融入一个宏环基基基.
- 稳定螺旋结构使用重的替代剂在paracyclophane单元.
- 通过化,交叉合和高稀释的宏循环合成.
- 使用NMR光谱,质谱和循环二极化 (CD) 光谱进行表征.
- 通过将CD数据与TD-DFT计算进行比较来确定绝对配置.
- 使用动态HPLC和可变温度二维交换光谱学的反化动态研究.
主要成果:
- 一个新型螺旋宏循环1的成功合成,其中包含一个 [2.2] paracyclophane 单元.
- 在宏观循环中, [2.2] 环旋部分诱导了螺旋形状.
- 帕西克洛芬的大量替代剂显著增加了反化障碍.
- 状宏循环的反体已成功分离.
- 确定了绝对配置,并彻底研究了反化动态.
结论:
- 将 [2.2] 抛物线集成到宏循环中是一种稳定螺旋状结构的有效策略.
- 开发的方法允许合成和分离纯状化合物.
- 这项工作为设计和访问复杂的性分子提供了一个新的平台,在材料科学和不对称合成中具有潜在的应用.
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