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激活的PMN外体:致病性实体导致肺部的基质破坏和疾病

Kristopher R Genschmer1, Derek W Russell1, Charitharth Lal2

  • 1Department of Medicine, Division of Pulmonary, Allergy, and Critical Care, The University of Alabama at Birmingham, Birmingham, AL 35294, USA; Lung Health Center, The University of Alabama at Birmingham, Birmingham, AL 35294, USA; Program in Protease and Matrix Biology, The University of Alabama at Birmingham, Birmingham, AL 35294, USA.

Cell
|January 12, 2019
PubMed
概括

新型中性粒细胞衍生外体携带中性粒细胞弹性酶 (NE),通过降解细胞外基质导致慢性阻塞性肺病 (COPD) 和支气管肺功能失调 (BPD). 这些外体对抑制剂具有耐药性,并转移疾病表型.

关键词:
美国慢性肺炎其他:弹性酶的使用外体细胞细胞外基质细胞外囊泡炎症的发生肺部疾病微粒中性细胞

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