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Updated: Jan 30, 2026

Two- and Three-Dimensional Live Cell Imaging of DNA Damage Response Proteins
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细菌对人类的蛋白质网络揭示了内生DNA损伤的起源

Jun Xia1, Li-Ya Chiu2, Ralf B Nehring3

  • 1Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA; Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA; Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA; Graduate Program in Integrative Molecular and Biomedical Sciences, Baylor College of Medicine, Houston, TX 77030, USA.

Cell
|January 12, 2019
PubMed
概括

科学家发现了DNA损伤蛋白 (DDPs) 过量产生时会导致DNA损伤. 这些蛋白质与人类的癌症发展和不良预后有关,突出显示它们在突变发生过程中的作用.

关键词:
对DNA损伤的反应DNA 双链断裂DNMT1的使用情况大肠杆菌癌症一个进化基因组的不稳定性人类细胞微生物癌症模型复制叉反转

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