概括
在非常早产的婴儿中,肠道补充乳酸并没有减少晚发性感染. 这项大规模的试验表明,牛乳不是常规推用于预防这种脆弱人群的感染.
科学领域:
- 新生儿医学
- 传染性疾病
- 临床试验
背景情况:
- 在医院获得的感染对非常早产婴儿构成重大风险.
- 之前的研究表明,补充乳酸可以预防感染.
- 这项试验旨在在更大群体中验证这些发现.
研究的目的:
- 确定肠道牛乳是否可以减少早产婴儿的晚期感染.
- 为临床实践准则提供强有力的证据.
主要方法:
- 这是一项大型随机化,安慰剂对照试验,涉及37家英国医院的2203名早产婴儿.
- 婴儿每天接受牛乳或糖,直到34周的月经后.
- 主要结局是微生物学证实或临床怀疑的晚期感染.
主要成果:
- 乳酸组 (29%) 和对照组 (31%) 的晚发感染率没有显著差异.
- 经调整的感染风险比为0. 95 (95% CI为0. 86-1. 04; p=0. 233).
- 严重的不良事件相似,其中两个可能与乳素有关.
结论:
- 肠道牛乳补充剂并不能有效降低非常早产婴儿晚发感染的风险.
- 目前的证据不支持在该群体中常规使用乳酸预防感染.
- 可能需要进一步的研究来探索特定的子组或替代干预措施.
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