使用合成水凝模仿活性生物聚合物网络
Marcos Fernández-Castaño Romera1, Robert Göstl, Huda Shaikh
1SupraPolix BV , Horsten 1 , 5612 AX , Eindhoven , The Netherlands.
Journal of the American Chemical Society
|January 15, 2019
概括
合成聚合物在加热时会显著硬, 这种从液体变成凝的材料可以为医疗应用提供新的生物材料.
科学领域:
- 生物材料科学
- 聚合物化学
- 生物物理
背景情况:
- 生物系统利用内部压力产生生物机械过程,例如细胞硬化周围的矩阵和分子电机改变细胞骨特性.
- 了解合成材料的压力产生是模仿生物功能的关键.
研究的目的:
- 用热敏聚合物交叉连接的合成纤维基质来证明内部应力产生和宏观硬.
- 研究可调节机械性能的合成材料的设计潜力.
主要方法:
- 合成半柔性聚合物基质与热敏聚烯酸胺 (PNIPAM) 的化学交联.
- 在PNIPAM中通过越过其较低的临界溶液温度来诱导线圈到球体的过渡.
- 在剪切应力下测量模块变化和功率规律的风学分析.
主要成果:
- 在PNIPAM从线圈到球体过渡时,交叉连接的纤维基表现出一个宏观的硬化反应,其模量超过3个数量级.
- 由PNIPAM崩产生的力量在几秒钟内迅速将液体材料转化为硬凝.
- 化的网络显示了与预应力生物网络相匹配的强度规律的硬化.
结论:
- 热反应性聚合物诱导的内部应力为合成纤维材料提供了快速,大规模硬化的机制.
- 观察到的机械性质,包括动力规律的质学,类似于生物组织,如原蛋白和actomyosin网络.
- 这种方法为开发先进的合成水凝提供了途径,在体温下从液体转变为固体,模仿细胞和组织机制.
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