对于社交和养行为而言,轨道前皮层中的交互神经集群
Joshua H Jennings1, Christina K Kim2, James H Marshel1
1Department of Bioengineering, Stanford University, Stanford, CA, USA.
Nature
|January 18, 2019
概括
在轨道前皮层的不同神经元群体双向控制养行为. 激活与食相关的神经元会增加食物摄入量, 而激活社会神经元则会抑制食物摄入量,
科学领域:
- 神经科学
- 行为科学
- 计算神经科学
背景情况:
- 基本的驱动力如食和社交互动相互影响, 有适应性和不适应性后果.
- 对于热量摄入和社会行为的神经系统是重叠的, 但它们相互作用的因果机制仍然不清楚.
- 轨道前皮层 (OFC) 处理奖励,并包含对热量和社会刺激作出反应的多种神经元群体.
研究的目的:
- 调查细胞分辨率的因果作用,经验特异性神经元群体在OFC上的行为.
- 了解竞争驱动器,特别是养和社会行为的判断基础上的电路机制.
主要方法:
- 结合基因编码活动成像与单独定义的OFC神经元的光遗传控制.
- 在热量消耗和社交互动期间实时监控和操纵单个神经元活动.
- 利用细胞分辨率技术评估特定神经元群体激活的行为影响.
主要成果:
- 在OFC中识别出不同的神经元群体,选择性地对热量奖励或社会刺激做出反应.
- 导致了个体食反应神经元的活动与食行为的增加.
- 证明激活社会响应神经元会抑制养,而激活非响应神经元则没有影响.
结论:
- 在OFC中发现了强大的细胞级子网络,
- 展示了特定神经元群体根据社会背景调节养的精确参与.
- 提供了一个理解大脑如何在单细胞水平上判断竞争驱动的框架.
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