对宏观力量的分子控制驱动脊椎动物后肠的形成
Nandan L Nerurkar1,2,3, ChangHee Lee4, L Mahadevan5,6,7,8
1Department of Genetics, Harvard Medical School, Boston, MA, USA. nln2113@columbia.edu.
Nature
|January 18, 2019
概括
早期的胚胎肠道管形成,特别是后肠发育,是由集体细胞运动和收缩力梯度驱动的. 这种渐变受纤维细胞生长因子信号的影响,引导组织延长和细胞招募到适当的器官生成.
科学领域:
- 发育生物学
- 细胞生物学
- 生物物理
背景情况:
- 胚胎肠道管是呼吸道和胃肠道的基础.
- 研究了早期的内皮发育和后来的器官生成,但对肠道管形成的理解较少.
- 现有的模型描述了通过迁移门户 (AIP和CIP) 形成的肠道管,特别是前肠.
研究的目的:
- 研究早期胚胎肠道管形态的分子控制.
- 澄清后肠形成的独特机制.
- 确定推动后肠发育的信号通路和物理力量.
主要方法:
- 在胚胎的体内成像.
- 生物物理分析和数学建模.
- 分子和胚胎技术.
主要成果:
- 后肠是通过集体细胞移动而不是CIP迁移而形成的.
- 一个收缩力梯度驱动后肠的延伸.
- 纤维细胞生长因子 (FGF) 信号梯度建立了力梯度.
- 一个积极的反循环将细胞招募到延长的后肠.
结论:
- 后肠的发育与前肠形成有着不同的机制.
- 组织规模的力量对脊椎动物的形态发生至关重要,可以追溯到发育信号.
- FGF信号传递和细胞收缩性相互作用以驱动肠道管的延长.
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