的meta-C-H和ipso-C-O键的顺序功能化
Jiancong Xu1, Jingjing Chen1, Feng Gao1
1State Key Laboratory and Institute of Elemento-organic Chemistry, College of Chemistry , Nankai University , Tianjin 300071 , China.
Journal of the American Chemical Society
|January 23, 2019
概括
一种新型的双功能模板使的单序列C-H化和C-O化成为可能. 这种策略有效地从简单的中合成有价值的1,3-非替代.
科学领域:
- 有机化学
- 催化剂
- 合成方法
背景情况:
- 这是一个强大的合成策略.
- 模板导向的方法提供了独特的C-H激活控制.
- 的顺序功能化仍然是一个挑战.
研究的目的:
- 开发一种可用的模板导向方法,用于的顺序C-H功能化.
- 在单过程中实现元选择性C-H化和ipso-C-O化.
- 为了高效地合成1,3-非替代.
主要方法:
- 使用双功能模板进行功能化.
- 在元位置采用催化C-H化.
- 使用催化C-O激活和随后在ipso位置的arylation.
- 进行了一次性的反应.
主要成果:
- 成功演示了一个模板导向的,单位序列功能化.
- 实现了超选择性的C-H化和ipso-C-O化.
- 合成了各种高效率的1,3-非替代体.
- 这种双功能模板对于指导顺序反应至关重要.
结论:
- 开发了一种高效和多用途的方法,用于从中合成1,3-非替代性.
- 以模板为导向的策略使单个中的顺序C-H和C-O债券功能化成为可能.
- 这种方法扩大了复杂分子合成中的的实用性.
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