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多发性硬化症中的寡细胞生成动力学
Maggie S Y Yeung1, Mehdi Djelloul1, Embla Steiner1
1Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden.
Nature
|January 25, 2019
概括
在多发性硬化症中,新型寡细胞的产生在侵袭性病例中增加,但在大多数患者中失败. 病变中的雷米林化可能不涉及新细胞,这表明新的治疗点.
科学领域:
- 神经科学
- 免疫学
- 细胞生物学
背景情况:
- 在中枢神经系统中形成髓层.
- 多发性硬化症 (MS) 涉及免疫介导的髓破坏,具有再生的潜力.
- 动物模型显示新的寡细胞再生髓,但人类的相关性尚不清楚.
研究的目的:
- 研究人类多发性硬化症中的寡细胞生成动态.
- 评估动物模型是否准确地反映了人类的复髓化过程.
主要方法:
- 从核试验中利用的14C集成到基因组DNA中,
- 在MS患者中分析了正常白质和影子斑块的寡细胞生成.
主要成果:
- 在侵袭性多发性硬化症患者中,骨髓质细胞的生成显著增加,但大多数患者并非如此.
- 在MS影子斑块中发现的寡细胞是旧的,而不是新产生的.
- 这表明许多多发性硬化症患者固有的寡细胞生成潜力失败.
结论:
- 在多发性硬化症中,寡细胞生成的动态是意想不到的,与动物模型不同.
- 在多发性硬化病变中,转基因化可能不会导致新的寡细胞形成.
- 这些发现需要重新评估当前的治疗方法,并开发新的针对复髓化的治疗方法.
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