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相关概念视频

The Synapse02:47

The Synapse

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Neurons communicate with one another by passing on their electrical signals to other neurons. A synapse is the location where two neurons meet to exchange signals. At the synapse, the neuron that sends the signal is called the presynaptic cell, while the neuron that receives the message is called the postsynaptic cell. Note that most neurons can be both presynaptic and postsynaptic, as they both transmit and receive information.
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Hormonal Regulation01:40

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Hormones regulate a significant portion of digestion through activation of the neuroendocrine system. The neuroendocrine system of digestion contains many different hormones all with multiple functions that are both, directly and indirectly, involved in digestion.
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GTPases and their Regulation02:14

GTPases and their Regulation

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Guanine nucleotide-binding proteins (G-proteins), also known as GTPases, are a superfamily of proteins that regulate many cellular processes, such as cell signaling, vesicular transport, and the regulation of cell shape and motility. Mutation or dysfunction of these proteins can lead to disease. There are around 40,000 known G-proteins that can broadly be classified into two groups ‒  small G-proteins consisting of a single domain and large multi-domain G-proteins.
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Electrical Synapses01:28

Electrical Synapses

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Electrical synapses found in all nervous systems play important and unique roles. In these synapses, the presynaptic and postsynaptic membranes are very close together (3.5 nm) and are actually physically connected by channel proteins forming gap junctions.
Gap junctions allow the current to pass directly from one cell to the next. In contrast, in the chemical synapse, the neurotransmitters carry the information through the synaptic cleft from one neuron to the next. They consist of two...
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Chemical Synapses01:26

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Chemical synapses are specialized sites between two neurons or between a neuron and a non-neuronal cell like a muscle, glandular or sensory cell.
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Chemical synapses are specialized sites between two neurons or between a neuron and a non-neuronal cell like a muscle, glandular or sensory cell.
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Mapping Inhibitory Neuronal Circuits by Laser Scanning Photostimulation
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不同的分子程序调节皮质抑制电路中的突触特异性

Emilia Favuzzi1,2,3, Rubén Deogracias1,2,3, André Marques-Smith1,2

  • 1Centre for Developmental Neurobiology, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE1 1UL, UK.

Science (New York, N.Y.)
|January 26, 2019
PubMed
概括
此摘要是机器生成的。

特定的分子程序指导GABAergic内部神经元如何在小鼠大脑中连接. 这些细胞特异性程序决定突触向, 塑造抑制电路的形成和大脑功能.

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科学领域:

  • 神经科学
  • 分子生物学
  • 发育生物学

背景情况:

  • 神经连接形成了对认知功能至关重要的功能性脑网络.
  • 哺乳动物大脑皮层中的GABA活体内神经元显示出时间动态和信息处理所必需的多种连接模式.
  • 驱动内部神经元特定连接的分子机制在很大程度上是未知的.

研究的目的:

  • 在小鼠皮层抑制电路发育过程中研究不同类型内部神经元的转录动态.
  • 阐明内部神经元特异性突触向的分子基础.

主要方法:

  • 在不同的内部神经元亚型中分析转录动态.
  • 在出生后早期研究突触分子表达模式.

主要成果:

  • 在金字塔细胞 (树突, soma 或轴突初始段) 上的神经元内突触的形成是由突触分子的亚型特异表达决定的.
  • 在电路形成过程中,不同的分子程序在不同的内部神经元中活跃.

结论:

  • 在早期发育过程中建立的细胞特异性分子程序是皮层内神经元的精确连接模式的基础.
  • 了解这些程序是解读抑制电路组合和功能的关键.