登革热
Annelies Wilder-Smith1, Eng-Eong Ooi2, Olaf Horstick3
1London School of Hygiene & Tropical Medicine, London, UK; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore; Heidelberg Institute of Global Health, University of Heidelberg, Heidelberg, Germany.
Lancet (London, England)
|January 31, 2019
概括
尽管死亡率很低, 但严重的登革热对健康造成重大负担. 研究正在推进诊断,治疗和疫苗, 但在预测严重疾病和了解疫苗有效性方面仍然存在挑战.
科学领域:
- 医学昆虫学
- 传染性疾病
- 疫苗学
背景情况:
- 严重的登革热在流行地区造成了巨大的经济和卫生服务负担.
- 尽管了解病变的进展, 但登革热治疗的发展仍滞后.
- 抗体依赖增强是一种关键的登革热致病模型,最近在体内得到了验证.
研究的目的:
- 审查目前的登革热管理,诊断和预防情况.
- 突出正在进行的治疗,诊断和疫苗研究.
- 强调需要改进严重登革热预测和干预策略.
主要方法:
- 审查目前的登革热管理策略,包括支持性护理和补水.
- 讨论新兴的诊断技术,如临床核酸放大试验.
- 检查疫苗开发,包括血清状况和保护相关的作用.
主要成果:
- 目前的管理依赖于观察和补水以发现血管泄漏.
- 新的诊断工具旨在提高准确性和多重复合能力.
- 生物标志物研究旨在预测严重的登革热;疫苗的有效性取决于血清状况.
结论:
- 迫切需要有效的登革热疗法和可靠的生物标志物来预测严重的疾病.
- 了解疫苗保护和疾病增强的相关性至关重要.
- 将病媒控制与疫苗接种战略相结合需要进一步的研究和评估.
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