基于原料的氧化合成方法的开发
Kevin Hung1, Matthew L Condakes1, Luiz F T Novaes1
1Department of Chemistry , University of California, Berkeley , 826 Latimer Hall , Berkeley , California 94720 , United States.
Journal of the American Chemical Society
|January 31, 2019
概括
研究人员从 (+) 中开发了一种半合成策略,以制造伊利石. 这种方法成功合成了十多种复杂的天然产物,包括伪氨酸和氨酸,提供了对C ((sp3) -H功能化的见解.
科学领域:
- 自然产品化学
- 有机合成
- 生物合成仿真
背景情况:
- 基是一种多样化的类别,包含100多种天然产品.
- 许多类具有显著的生物活性.
- 它们复杂的结构带来了合成的挑战.
研究的目的:
- 开发一个半合成策略的伊利石.
- 模仿它们假定生物合成的关键方面.
- 从丰富的原料中获取结构复杂的天然产品.
主要方法:
- 从 (+) 开始半合成.
- 代路线开发,包括第二代战略.
- 专注于对位点选择性的C ((sp3) -H键的功能化.
主要成果:
- 一个成功的合成的伪anisatinoids 和 allo-cedrane 天然产品11-O-debenzoyltashironin.
- 获取高氧化素化合物,包括基和素.
- 从 (+) 中总共合成了12种天然产品.
- 报告了关于多环系统中C ((sp3) -H功能化的一般性观察.
结论:
- 一个强大的半合成策略可以获得广泛的伊利石.
- 该方法为生物合成途径和C ((sp3) -H功能化提供了宝贵的见解.
- 使用丰富的 (+) 作为原料是经济可行的.
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