突发死亡和左心室参与心律失常
在PubMed上查看摘要
概括
此摘要是机器生成的。节律失调性心肌病 (ACM) 导致突然心脏死亡 (SCD),主要发生在男性和运动员身上,往往没有先前的症状. 尸体解剖显示左心室经常受到影响, 这表明目前的诊断标准可能错过了双心室ACM病例.
科学领域
- 心脏病学
- 病理学
- 遗传学
背景情况
- 节律失调性心肌病 (ACM) 是一种遗传性心脏疾病,导致纤维脂肪替代和突然心脏死亡 (SCD).
- 最初被认为是右心室疾病,现在被认为是双心室疾病.
- 这项研究研究了大量心脏突发死亡病例的病理,遗传和临床因素.
研究的目的
- 调查心律失常性心肌病 (ACM) 在突然心脏死亡 (SCD) 病例中的特征.
- 评估ACM中双心脏干扰的发生率.
- 评估ACM目前的诊断标准的有效性.
主要方法
- 在25年间对5205例心脏突发死亡 (SCD) 的分析.
- 专家进行心脏病学检查和组织学评估.
- 记录临床病史,症状和参与竞技运动;死后基因检测在子集中进行.
主要成果
- 诊断出有202例 (4%), 主要是男性 (82%) 和年轻人 (平均年龄为35. 4岁).
- 78% 的 ACM 患者以前没有心脏症状; 20% 是竞技运动员.
- 在87%的病例中发现左心室参与,70%的病例中发现双心室疾病;在25%的测试病例中,与ACM相关的基因具有致病变体.
结论
- 由于ACM引起的突然心脏死亡 (SCD) 主要影响男性,通常在运动员没有先前症状时发生.
- 在尸检诊断的ACM中,左心室受影响很常见.
- 目前的诊断标准可能无法在死亡之前充分识别双心脏ACM.
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