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修改PKG1的TSC2调节mTORC1活动以应对不良的心脏压力

Mark J Ranek1, Kristen M Kokkonen-Simon1, Anna Chen1

  • 1Division of Cardiology, Department of Medicine, The Johns Hopkins Medical Institutions, Baltimore, MD, USA.

Nature
|February 1, 2019
PubMed
概括

在特定的血清位点化素 (TSC2) 双向控制mTORC1活动,这对心脏保护至关重要. 这种TSC2酸化对于蛋白激酶G1 (PKG1) 介导的心脏保护对压力过载至关重要.

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