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肠内皮质T细胞对新陈代谢进行校准,加速心血管疾病
Shun He1, Florian Kahles2, Sara Rattik2
1Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. SHE6@mgh.harvard.edu.
Nature
|February 1, 2019
概括
肠道中的免疫细胞,自然内皮T淋巴细胞 (IELs),调节新陈代谢. 缺乏IEL可以防止肥胖和糖尿病等代谢疾病,
科学领域:
- 免疫学
- 代谢科学
- 胃肠病学
背景情况:
- 精确调节对食物摄入的生化反应对健康至关重要.
- 代谢传感器将营养摄入与中间代谢联系起来.
- 免疫细胞在调节全身新陈代谢方面发挥作用.
研究的目的:
- 研究肠内皮质T淋巴细胞 (IEL) 在全身代谢调节中的作用.
- 确定IEL对代谢疾病的影响.
- 阐明IELs控制新陈代谢平衡的机制.
主要方法:
- 使用缺乏自然IEL的整合蛋白β7的小鼠.
- 用高脂肪和高糖饮食来研究代谢反应.
- 研究GLP-1及其受体在IEL介导的代谢控制中的作用.
主要成果:
- 缺乏自然IEL的小鼠表现出代谢过活和对肥胖,高胆固醇,高血压,糖尿病和动脉样硬化的抵抗力.
- 在IEL缺乏的小鼠中,对心血管疾病的保护依赖于GLP-1.
- IELs通过调节GLP-1的生物可用性来控制肠内分泌活性,作为门卫.
结论:
- 肠道IEL是系统代谢的关键调节剂.
- 缺乏IEL可以防止饮食引起的代谢疾病.
- 在现代饮食中,IEL介导的代谢控制可能是有害的,有助于疾病的发病.
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