探测基于Imine的五叶式结和Pentameric圆形螺旋组件的动力
Jean-François Ayme1,2, Jonathon E Beves2, Christopher J Campbell2
1School of Chemistry , University of Manchester , Oxford Road , Manchester M13 9PL , United Kingdom.
Journal of the American Chemical Society
|February 2, 2019
概括
自组装的分子结和螺旋体显示有效的错误校正. 尽管没有达到完全的热力学控制,但这些复杂的结构可靠地形成,显示出强大的自组装动力学.
科学领域:
- 超分子化学
- 协调化学
- 有机合成
背景情况:
- 以胺为基础的五叶状结和五叶状圆形螺旋体是复杂的金属-超分子结构.
- 这些结构是使用二甲) 二甲基,铁) 和氨基组装的.
研究的目的:
- 研究基于 imine 的五叶式结和圆形螺旋体的自组装动力学和错误纠正机制.
- 为了比较开放的圆形螺旋旋和闭环五叶旋结之间的交换动态.
主要方法:
- 使用铁化物和各种氨基酸合成以胺为基础的五叶片结和五圆形螺旋体.
- 在不同的条件下 (例如温度,溶剂,时间) 使用标记和未标记的构成块进行组件交换动态的分析.
主要成果:
- 在四天内,圆形螺旋体中发生了周围N-基残留的完全交换.
- 在开放的圆形螺旋体 (13天) 中观察到完全的二甲构成块交换,但在五叶形螺旋体中显著减缓 (> 60天).
- 这两种结构在热力学控制下自组装,但在达到完全热力学平衡之前达到最大产量.
结论:
- 在合成过程中,以胺为基础的分子结和螺旋体具有高度有效的错误校正.
- 即使在没有完全的热力学控制下运行,自组装过程也表现出强度.
- 了解这些动态对于复杂的超分子结构的合理设计至关重要.
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