通过先天性淋巴细胞对脂质腺体进行静态控制,调节共生细菌平衡
Tetsuro Kobayashi1, Benjamin Voisin1, Do Young Kim2
1Cutaneous Leukocyte Biology Section, Dermatology Branch, NIAMS, NIH, Bethesda, MD 20892, USA.
Cell
|February 5, 2019
概括
皮肤内生淋巴细胞 (ILC) 通过与脂质腺相互作用来调节皮肤屏障和微生物平衡. 这种免疫-上皮沟通对于宿主-微生物共生至关重要.
科学领域:
- 免疫学
- 微生物学
- 皮肤病学
- 微生物组研究
背景情况:
- 皮肤的免疫细胞和上皮与微生物形成共生关系.
- 在皮肤屏障上调节微生物共生的机制尚不清楚.
- 天生的淋巴细胞 (ILC) 是屏障组织中的关键免疫参与者.
研究的目的:
- 调查皮肤居民ILC的空间组织和功能.
- 阐明ILCs在调节脂质腺和皮肤共生中的作用.
- 了解控制宿主微生物共生的免疫上皮电路.
主要方法:
- 在皮肤内存在的ILC的空间分区分析.
- 研究ILC对IL-7和胸膜淋巴细胞蛋白 (TSLP) 的依赖性.
- 通过化学因子受体CCR6进行ILC局部化的评估.
- 对TNF受体连接体表达和Notch信号通路调节的分析.
- 在ILC损失时评估脂质腺的大小和脂质产量.
- 对共生细菌的微生物社区概况.
主要成果:
- 一个RORγt+ ILCs子集位于脂质腺附近的毛囊中,调节它们的功能.
- ILC的持续性和局部性取决于IL-7,TSLP和CCR6.
- 由ILC衍生的TNF受体配体通过抑制Notch信号来限制血红细胞的生长.
- ILCs的损失导致脂质腺增生,抗菌脂质增加,以及改变了Gram阳性细菌群落.
结论:
- 皮质衍生信号保持皮肤常驻的ILC.
- ILCs通过皮肤屏障的脂质腺调节来调节微生物共生.
- 这项研究突出了对宿主微生物共生至关重要的免疫上皮电路.
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