不对称的白酸总合成
Xin Liu1,2, Junyang Liu1,3, Jianlei Wu1
1Shenzhen Grubbs Institute, Department of Chemistry , Southern University of Science and Technology , Shenzhen 518055 , China.
Journal of the American Chemical Society
|February 6, 2019
概括
研究人员报告了第一个不对称的酸三的合成. 这项研究利用II型分子内 [5 + 2] 循环添加来构建复杂的bicyclo[4.4.1]系统,克服了重要的合成挑战.
科学领域:
- 有机化学
- 合成化学
背景情况:
- 乙烯基酸是一种高度应变的天然产品.
- 应力环系统的合成在有机化学中提出了重大挑战.
研究的目的:
- 实现第一个不对称的酸三的总合成.
- 开发高效的合成策略来构建复杂,紧张的分子架构.
主要方法:
- 使用了II型分子内 [5 + 2] 循环添加反应.
- 随后使用过环循环来安装关键功能组.
主要成果:
- 合成成功构建了具有挑战性的bicyclo[4.4.1]环系统.
- 在最终产品中加入了应力桥头 (抗Bredt) 双键.
- 乙烯基cyclopropane部分被安装在保留立体化学.
结论:
- 报告的合成提供了一条可行的途径,即基酸-III.
- 使用的循环添加和循环化策略对于构建应力多环系统是有效的.
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