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Updated: Jan 29, 2026

Author Spotlight: Intrathecal Injection – An Efficient and Reliable Delivery Method to Test the Efficacy of Gene Editing in Neonatal Mouse Brains
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Author Spotlight: Intrathecal Injection – An Efficient and Reliable Delivery Method to Test the Efficacy of Gene Editing in Neonatal Mouse Brains

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纳米级的ATP-响应性地质性伊米达框架-90作为细胞蛋白输送和基因组编辑的一般平台

Xiaoti Yang1,2, Qiao Tang1,3, Ying Jiang1

  • 1Beijing National Laboratory for Molecular Science, CAS Research/Education Center for Excellence in Molecule Science, Key Laboratory of Analytical Chemistry for Living Biosystems , Institute of Chemistry, the Chinese Academy of Sciences (CAS) , Beijing 100190 , China.

Journal of the American Chemical Society
|February 7, 2019
PubMed
概括

研究人员开发了对ATP有反应的化物伊米达框架-90 (ZIF-90) 纳米颗粒,用于将蛋白质和CRISPR/Cas9输入细胞. 这些纳米载体在响应ATP时有效地释放载荷,显示出针对性疾病治疗的前景.

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