增加癌症可塑性的替代脂肪酸脱途径的证据
Kim Vriens1,2, Stefan Christen1,2, Sweta Parik1,2,3,4
1Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, VIB, Leuven, Belgium.
Nature
|February 8, 2019
概括
癌细胞通过利用另一种脂肪酸脱途径来产生沙皮亚酸,绕过已知的机制,表现出代谢可塑性. 针对这个和标准途径对于抑制癌细胞增殖至关重要.
科学领域:
- 生物化学
- 癌症生物学
- 代谢研究
背景情况:
- 瘤经常表现出改变的脂质代谢以支持快速增殖.
- 向脂肪酸代谢是有前途的,但只能在特定的癌症亚群中有效,这表明尚未探索的代谢途径.
研究的目的:
- 为了研究癌细胞中的代谢可塑性与脂肪酸脱有关.
- 确定癌细胞用于支持增殖的替代途径.
主要方法:
- 对癌细胞系,小鼠肝细胞癌和人类肝脏和肺癌的分析.
- 研究棕酸盐的脱和其在膜生物合成中的作用.
主要成果:
- 在各种癌症类型中识别了 sapienate生物合成作为替代性脂肪酸脱途径.
- 已经证明,酸盐的产生使得癌细胞能够绕过酸-CoA脱酶通路.
- 证实抑制这两种脱途径是必要的,以损害合成酸盐的癌细胞的增殖.
结论:
- 在癌细胞中发现了一种新的代谢可塑性机制,
- 突出了癌症中尚未研究的新陈代谢,
- 强调需要针对多种脂肪酸脱途径进行有效的癌症治疗.
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