Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Chemical Agents for Microbial Control01:27

Chemical Agents for Microbial Control

880
Chemicals play important roles in controlling microbial growth by targeting microbial structures and functions as sanitizers, antiseptics, disinfectants, and sterilants.Alcohols are commonly used sanitizers, effectively disrupting lipid membranes, which compromises cell integrity. They are also used as antiseptics and disinfectants due to their rapid action and versatility.Phenols and their derivatives phenolics , known for denaturing proteins and disrupting cell membranes, are particularly...
880
Introduction to Statistical Process Control01:15

Introduction to Statistical Process Control

641
Statistical Process Control (SPC) is a method used to monitor and control quality within processes, particularly in manufacturing and service delivery, by employing statistical methods. SPC aims to distinguish between natural (common cause) variation and variation due to specific changes or events (special cause), allowing for timely improvements and sustained quality. The control chart, a pivotal tool in SPC, visually displays data over time alongside a central line of upper and lower control...
641
Dynamic Equilibrium02:20

Dynamic Equilibrium

62.4K
A reversible chemical reaction represents a chemical process that proceeds in both forward (left to right) and reverse (right to left) directions. When the rates of the forward and reverse reactions are equal, the concentrations of the reactant and product species remain constant over time and the system is at equilibrium. A special double arrow is used to emphasize the reversible nature of the reaction. The relative concentrations of reactants and products in equilibrium systems vary greatly;...
62.4K
Chemical Equations03:10

Chemical Equations

81.3K
Chemical equations represent the identities and relative quantities of substances involved in a chemical reaction. The substances undergoing reaction are called reactants, and their formulas are placed on the left side of the equation. The substances generated by the reaction are called products, and their formulas are placed on the right side of the equation. Plus signs (+) separate individual reactant and product formulas, and an arrow (→) separates the reactant and product (left and right)...
81.3K
Chemical Reactions01:19

Chemical Reactions

95.6K
A chemical reaction is a process by which the bonds in the atoms of substances are rearranged to generate new substances. Matter cannot be created or destroyed in a chemical reaction—the same type and number of atoms that make up the reactants are still present in the products. Merely, the rearrangement of chemical bonds produces new compounds.
Chemical Reactions Rearrange Atoms into New Substances
A chemical reaction takes starting materials—the reactants—and changes them...
95.6K
Chemical Formulas02:52

Chemical Formulas

61.2K
A chemical formula presents information about the proportions of atoms constituting a particular chemical compound or molecule, mainly using symbols of elements and numbers. At times other symbols, such as dashes, parentheses, brackets, commas, plus, and minus signs, are also used. A chemical formula can be one of three types – molecular, empirical, and structural.
61.2K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

MEK interactions tune RAF kinase sensitivity to conformation-selective inhibition.

Nature chemical biology·2026
Same author

scAmp analyzes focal gene amplifications at single-cell resolution.

bioRxiv : the preprint server for biology·2026
Same author

Multiplex design and discovery of proximity handles for programmable proteome editing.

bioRxiv : the preprint server for biology·2025
Same author

Identification of affinity-optimized peptide binders of a viral protease for chemical genetic applications.

Bioorganic & medicinal chemistry letters·2025
Same author

Archaeal protein containing domain of unknown function 2193 undergoes oligomeric reconfiguration upon iron-sulfur cluster binding.

FEBS letters·2025
Same author

Late-Stage Reshaping of Phage-Displayed Libraries to Macrocyclic and Bicyclic Landscapes using a Multipurpose Linchpin.

Journal of the American Chemical Society·2024

相关实验视频

Updated: Jan 29, 2026

Generating Controlled, Dynamic Chemical Landscapes to Study Microbial Behavior
10:07

Generating Controlled, Dynamic Chemical Landscapes to Study Microbial Behavior

Published on: January 31, 2020

6.6K

通过化学干扰控制动态细胞过程的近距离系统

Daniel Cunningham-Bryant, Emily M Dieter, Glenna W Foight

    Journal of the American Chemical Society
    |February 9, 2019
    PubMed
    概括
    此摘要是机器生成的。

    我们开发了一个化学干扰的近距离 (CDP) 系统来控制蛋白质相互作用. 这种方法使用型肝炎病毒蛋白酶 (HCVp) 抑制剂快速破坏蛋白质结合,使细胞过程的时间控制成为可能.

    更多相关视频

    Light-Controlled Fermentations for Microbial Chemical and Protein Production
    08:37

    Light-Controlled Fermentations for Microbial Chemical and Protein Production

    Published on: March 22, 2022

    4.6K
    Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
    10:28

    Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers

    Published on: September 20, 2018

    6.9K

    相关实验视频

    Last Updated: Jan 29, 2026

    Generating Controlled, Dynamic Chemical Landscapes to Study Microbial Behavior
    10:07

    Generating Controlled, Dynamic Chemical Landscapes to Study Microbial Behavior

    Published on: January 31, 2020

    6.6K
    Light-Controlled Fermentations for Microbial Chemical and Protein Production
    08:37

    Light-Controlled Fermentations for Microbial Chemical and Protein Production

    Published on: March 22, 2022

    4.6K
    Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
    10:28

    Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers

    Published on: September 20, 2018

    6.9K

    科学领域:

    • 分子生物学
    • 化学生物学
    • 合成生物学

    背景情况:

    • 蛋白质的空间接近对于生物功能至关重要.
    • 控制蛋白质相互作用的时间对于研究细胞过程和工程合成行为至关重要.

    研究的目的:

    • 开发一种新的化学控制方法来迅速破坏蛋白质与蛋白质的相互作用.
    • 使用新的近距离系统对细胞内过程进行时间控制.

    主要方法:

    • 开发了一种基于型肝炎病毒蛋白酶 (HCVp) NS3a和抑制剂的化学干扰接近 (CDP) 系统.
    • 使用临床批准的抗病毒药物作为化学诱导剂来破坏NS3a/相互作用.
    • 证明了对各种细胞内过程的时间控制.

    主要成果:

    • 通过CDP系统成功地证明了蛋白质结合的快速破坏.
    • 展示了对各种细胞内功能进行时间控制的能力.
    • 验证了现有的抗病毒抑制剂用于化学破坏.

    结论:

    • 基于NS3a的CDP系统为工程化学控制细胞内蛋白质功能提供了一个新工具.
    • 这种系统为调节蛋白相互作用的现有技术提供了一种补充方法.
    • 在生物研究和合成生物学应用中,CDP系统能够精确调节蛋白质的近距离.