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相关概念视频

Chromosome Replication02:31

Chromosome Replication

10.6K
Before a cell can divide, it must accurately replicate all of its chromosomes, including the DNA and its associated histone and non-histone proteins.  This process begins at numerous origins of replication during the S phase of the cell cycle in each of a cell’s chromosomes simultaneously. Certain nucleotides can act as origins of replication, but these sequences are not well defined - especially in complex, multi-cellular, eukaryotic species. The length of DNA that spans an origin...
10.6K
Genomics02:02

Genomics

40.5K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
40.5K
Genome Size and the Evolution of New Genes03:21

Genome Size and the Evolution of New Genes

9.1K
While every living organism has a genome of some kind (be it RNA, or DNA), there is considerable variation in the sizes of these blueprints. One major factor that impacts genome size is whether the organism is prokaryotic or eukaryotic. In prokaryotes, the genome contains little to no non-coding sequence, such that genes are tightly clustered in groups or operons sequentially along the chromosome. Conversely, the genes in eukaryotes are punctuated by long stretches of non-coding sequence.
9.1K
DNA Replication02:40

DNA Replication

59.1K
DNA replication involves the separation of the two strands of the double helix, with each strand serving as a template from which the new complementary strand is copied.  After replication, each double-stranded DNA includes one parental or “old” strand and one “new” strand. This is known as semiconservative replication. The resulting DNA molecules have the same sequence and are divided equally into the two daughter cells.
Replication in Prokaryotes
DNA replication...
59.1K
Replication in Prokaryotes02:35

Replication in Prokaryotes

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Overview
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Replication in Eukaryotes02:31

Replication in Eukaryotes

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Overview
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相关实验视频

Updated: Jan 29, 2026

Genome-wide Determination of Mammalian Replication Timing by DNA Content Measurement
08:06

Genome-wide Determination of Mammalian Replication Timing by DNA Content Measurement

Published on: January 19, 2017

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复制时间与3D基因组组织交织在一起

Jian Ma1, Zhijun Duan2

  • 1Computational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA 15213, USA.

Cell
|February 9, 2019
PubMed
概括

研究人员发现早期复制控制元素 (ERCE) 调节DNA复制时间和基因组组织. 这些cis作用元素为高阶基因组结构和功能提供了新的见解.

科学领域:

  • 基因组学
  • 分子生物学
  • 表观遗传学

背景情况:

  • 空间基因组组织影响各种基因组过程,包括DNA复制.
  • 了解控制复制时间的监管要素对于理解基因组功能至关重要.

研究的目的:

  • 研究空间基因组组织与DNA复制时间之间的关系.
  • 确定调节复制时间和基因组架构的新型cis作用元素.

主要方法:

  • 对空间基因组组织数据的分析.
  • 对DNA复制时间模式的剖析.
  • 识别和描述新的监管要素.

主要成果:

  • 早期复制控制元件 (ERCE) 的发现.
  • 发现ERCE可以调节复制时间.
  • ERCEs影响转录和多层的三维基因组组织.

结论:

  • 早期复制控制元件 (ERCE) 是一种新型的 cis 作用调节元件.
  • 这些发现对理解高阶基因组结构和功能的控制具有重要意义.

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Profiling DNA Replication Timing Using Zebrafish as an In Vivo Model System

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G2-seq: A High Throughput Sequencing-based Technique for Identifying Late Replicating Regions of the Genome
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G2-seq: A High Throughput Sequencing-based Technique for Identifying Late Replicating Regions of the Genome

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Genome-wide Determination of Mammalian Replication Timing by DNA Content Measurement

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G2-seq: A High Throughput Sequencing-based Technique for Identifying Late Replicating Regions of the Genome
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G2-seq: A High Throughput Sequencing-based Technique for Identifying Late Replicating Regions of the Genome

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  • 这项研究为进一步的基因组调控研究提供了基础.