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通过多糖 () 减轻因疏水引起的免疫毒性

Sampa Maiti¹, Saikat Manna², Jingjing Shen²

¹Department of Chemistry and Biochemistry, Science of Advanced Material , Central Michigan University Mount Pleasant , Michigan 48858 , United States.

Journal of the American Chemical Society

|February 16, 2019

概括

与传统材料相比,使用基于葡萄糖的支架的新型聚合物纳米粒子 (NP) 显示免疫毒性降低. 这种基于碳水化合物的方法为开发更安全的临床用生物材料提供了有希望的策略.

科学领域:

生物材料科学
纳米技术
免疫学

背景情况:

聚合物纳米粒子 (NP) 对临床应用具有前景,但面临免疫毒性挑战.
在NP中的疏水成分通常与不良的免疫反应有关.
基于碳水化合物的聚合物可能提供缓解NP诱导的免疫毒性的解决方案.

研究的目的:

设计和合成基于碳水化合物的新型NP系统.
在体外和体内评估这些新型NP的免疫毒性.
将基于碳水化合物的NP与由传统聚合物制成的NP的免疫毒性进行比较.

主要方法:

使用葡萄糖多聚) 作为疏水性支架和聚乙烯糖醇 (PEG) 作为疏水性外合成NP.
通过测量诱导的细胞因子水平进行NP免疫毒性的体外和体内评估.
使用聚酸 (PLA) 和聚烯酸 (PCL) 作为对照的疏水性支架进行免疫毒性比较分析.

主要成果:

新型基于葡萄糖的NP显示出显著的低免疫毒性.
基于碳水化合物的NP产生的细胞因子水平明显低于PLA或PCLNP产生的水平.
免疫学研究证实,碳水化合物聚合物可以减轻水性诱导的免疫毒性.

结论:

基于碳水化合物的聚合物可以有效地减轻NP中疏水性诱导的免疫毒性.
这些发现表明基于碳水化合物的聚合物是设计低免疫毒性生物材料的合适候选物.
开发的NP具有需要增强生物相容性的先进生物医学应用的潜力.

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