妇女突然心脏病死亡
M Anette E Haukilahti1, Lauri Holmström1, Juha Vähätalo1
1From Research Unit of Internal Medicine (M.A.E.H., L.H., J.V., T.K., J.T., J.P., H.H., M.J.J.), Medical Research Center Oulu, University of Oulu and University Hospital of Oulu, Finland.
Circulation
|February 20, 2019
概括
妇女的突然心脏死亡 (SCD) 通常发生在老年人群中,并没有缺血性原因. 虽然SCD的女性可能有正常的心电图,但他们也显示出更多的左心室缩标志物,表明复杂的风险因素.
科学领域:
- 心脏病学
- 病理学
- 医学研究
背景情况:
- 尽管心脏病管理方面取得了进展,但心脏病突发死亡 (SCD) 仍然是导致死亡的重要原因.
- 在女性中,SCD的风险概况和预防策略比男性少.
- 了解SCD的性别特异性机制和风险标志物对于改善结果至关重要.
研究的目的:
- 在大量患有SCD的女性中调查尸检结果和死亡原因.
- 为了比较女性和男性SCD的特征.
- 分析和分类与SCD相关的先前心电图 (ECG) 发现.
主要方法:
- 使用了来自Fingesture研究的数据,该研究收集了1998-2017年北芬兰的临床和尸检数据.
- 分析了5869名SCD患者的数据,重点是1101名患者 (25.3%的女性) 拥有可用的心电图.
- 在男性和女性SCD群体之间比较人口统计,尸检和心电图数据.
主要成果:
- 女性SCD受试者年龄大于男性 (70. 1岁).
- 缺血性心脏病是两性死亡的主要原因,但非缺血性原因在女性中更为普遍 (28.3%对24.3%).
- 女性心肌纤维化率较高,前期心电图正常,但心电图左心室缩标志物也较多.
结论:
- 女性在年龄较大时出现SCD,并且非缺血病因的可能性更高.
- 心肌纤维化在患有SCD的女性中发生率明显较高.
- 虽然SCD的女性可能呈现出正常的心电图,但特定的缩和复极异常更为常见,这表明了不同的风险概况.
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