临界期皮层局部树突突突变的神经调节控制
Courtney E Yaeger1, Dario L Ringach1,2, Joshua T Trachtenberg3
1Department of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Nature
|February 22, 2019
概括
早期的大脑发育依赖于由乙胆调节的特定抑制电路, 在关键时期塑造感官处理. 这条短暂的神经通道对视力至关重要,
科学领域:
- 神经科学
- 发育生物学
- 感官处理
背景情况:
- 在关键时期的早期感官体验对于神经电路的发展和信息处理至关重要.
- 皮质对感官输入的敏感性及其年龄相关的下降机制尚不清楚.
研究的目的:
- 调查抑制电路在视觉发育关键时期塑造树突活动的作用.
- 阐明双眼可塑性中体静止素 (SST) 表达内神经元的胆能调节的功能.
主要方法:
- 使用小鼠主要视觉皮层模型.
- 研究了乙胆对表达体质素 (SST) 的内部神经元和表达帕瓦胺的内部神经元的影响.
- 使用光遗传技术来操纵SST细胞的活动.
- 评估双眼受体场的发展和树突活动.
主要成果:
- 在关键时期的胆固醇信号激发SST内部神经元,抑制金字塔细胞并增强树突和体活性.
- 在成年后,这种胆固醇敏感性会减弱,从而导致细分树突反应的丧失.
- 对SST细胞的光遗传激活可以恢复成人树突反应,而在关键时期的抑制会损害双眼发育.
结论:
- 短暂的SST细胞胆固醇调节调节关键的神经可塑性特征,包括体性无抑制和细分型树突突突变.
- 这种调节的丧失可能是关键因素关闭关键时期的感官发展.
相关概念视频
The Periodic Table
111.5K
As early chemists discovered more elements, they realized that various elements could be grouped by their similar chemical behaviors. One such grouping includes lithium (Li), sodium (Na), and potassium (K). All of these elements are shiny, conduct heat and electricity well, and have similar chemical properties. A second grouping includes calcium (Ca), strontium (Sr), and barium (Ba), which also are shiny, good conductors of heat and electricity, and have chemical properties in common. However,...
111.5K
Periodic Classification of the Elements
58.9K
The periodic table arranges atoms based on increasing atomic number so that elements with the same chemical properties recur periodically. When their electron configurations are added to the table, a periodic recurrence of similar electron configurations in the outer shells of these elements is observed. Because they are in the outer shells of an atom, valence electrons play the most important role in chemical reactions. The outer electrons have the highest energy of the electrons in an atom...
58.9K
Critical Region, Critical Values and Significance Level
13.3K
The critical region, critical value, and significance level are interdependent concepts crucial in hypothesis testing.
In hypothesis testing, a sample statistic is converted to a test statistic using z, t, or chi-square distribution. A critical region is an area under the curve in probability distributions demarcated by the critical value. When the test statistic falls in this region, it suggests that the null hypothesis must be rejected. As this region contains all those values of the...
In hypothesis testing, a sample statistic is converted to a test statistic using z, t, or chi-square distribution. A critical region is an area under the curve in probability distributions demarcated by the critical value. When the test statistic falls in this region, it suggests that the null hypothesis must be rejected. As this region contains all those values of the...
13.3K
Critical Values
10.3K
A critical value is a definite value obtained from a particular probability distribution at a predecided confidence level (or a predecided significance level) for a given population parameter. The critical value provides demarcation that separates the sample statistics that are likely to occur from the ones that are unlikely to occur based on the given probability distribution and the population parameter to be estimated. The critical value for normal distribution is obtained from the z...
10.3K
Effective Value of a Periodic Waveform
1.2K
The concept of effective value, the root mean square (RMS) value, is crucial in understanding electrical circuits and power delivery. This idea emerges from the necessity to measure the effectiveness of a voltage or current source in supplying power to a resistive load.
The effective value of a periodic current represents the direct current (DC) that conveys the same average power to a resistor as the periodic current itself. This concept is crucial when assessing AC circuits. To determine the...
The effective value of a periodic current represents the direct current (DC) that conveys the same average power to a resistor as the periodic current itself. This concept is crucial when assessing AC circuits. To determine the...
1.2K
Critical Thinking I
5.1K
Critical thinking helps decision-making and allows nurses to recognize barriers to success and find solutions to possible issues. It helps to brainstorm and implement ideas to achieve goals. Critical thinking helps acknowledge and state workflow inefficiencies while improving management techniques. Nurses understand the value of critical thinking and look for fellow nurses with critical thinking skills to upgrade their professional standards. Critical thinking can advance a nurse's career...
5.1K


