概括
在冠状动脉旁路手术期间继续长期使用普拉诺洛尔化治疗是安全的. 这种方法减少了心痛和心律失常,而不是在手术前停止服用药物.
科学领域:
- 心脏病学 心脏病学
- 麻醉学 麻醉学
- 药理学 药理学是指药理学的学科.
背景情况:
- 长期的甲醇化物治疗对于心血管疾病是常见的.
- 这种治疗在冠状动脉旁路手术周围的最佳管理仍在争论中.
研究的目的:
- 为了前性地研究延续或停止甲醇化物治疗对接受冠状动脉旁路手术的患者的影响.
主要方法:
- 119名患者被分为三个组:持续的普罗兰诺洛,逐渐的普罗兰诺洛和没有普罗兰诺洛.
- 评估的结果包括胸痛症状,心室节律失常,手术内缺血,低血压,心和死亡率.
主要成果:
- 与停止治疗 (B组) 相比,继续使用普拉诺洛 (A组) 显示,心痛和心室节律失常增加的发作显著减少 (B组).
- 与对照组 (51%) 和B组 (70%) 相比,A组 (26%) 的手术内缺血的发生频率较低.
- 两组之间没有观察到低血压,心,绕道后出现,需要心脏刺激剂或死亡率的显著差异.
结论:
- 在冠状动脉旁路手术之前,继续长期使用全剂量的普拉诺洛尔化物治疗是安全和有益的.
- 这种策略似乎可以减轻术后心脏事件,如缺血和心律失常.
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