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Updated: Jan 28, 2026

Functional Assessment of BRCA1 variants using CRISPR-Mediated Base Editors
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细胞酶基编辑器在小鼠胚胎中产生了大量的非目标单核酸变体

Erwei Zuo1,2, Yidi Sun3, Wu Wei4,5,6

  • 1Institute of Neuroscience, State Key Laboratory of Neuroscience, Key Laboratory of Primate Neurobiology, CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai Research Center for Brain Science and Brain-Inspired Intelligence, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.

Science (New York, N.Y.)
|March 2, 2019
PubMed
概括

基因组编辑可以修复基因突变, 一种名为GOTI的新方法显示,CRISPR-Cas9和腺基编辑器具有较低的非目标突变,与细胞基编辑器不同.

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