素,但不是氨酸,基因编辑器诱导中的全基因组非目标突变

Shuai Jin1,2, Yuan Zong1,2, Qiang Gao3

  • 1State Key Laboratory of Plant Cell and Chromosome Engineering, Center for Genome Editing, Institute of Genetics and Developmental Biology, Innovative Academy of Seed Design, Chinese Academy of Sciences, Beijing 100101, China.

Science (New York, N.Y.)
|March 2, 2019
PubMed
概括

细胞因子和腺因基编辑器 (CBEs和ABEs) 对基因疗法具有前景. 然而,BE3和HF1-BE3基编辑器在米中诱导了显著的非目标突变,需要优化以获得更高的真实性.

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