在早期的Drosophila胚胎发生过程中,影响fushi tarazu细分基因的空间表达的zygotically活跃基因
Cell
|April 11, 1986
概括
了解虫的发育需要研究细分基因. 间隙和一些对规则基因的突变破坏了fushi tarazu (ftz) 基因.
科学领域:
- 发育生物学是发展生物学.
- 遗传学 是一个遗传学.
- 分子生物学分子生物学
背景情况:
- 德洛索菲拉 (Drosophila melanogaster) 作为研究胚胎发育的模型生物.
- 细分体模式的形成依赖于协调的基因活动.
- 发怒塔拉祖 (ftz) 基因是一个关键的对规则细分基因.
研究的目的:
- 研究早期发育基因突变对fushi tarazu (ftz) 基因空间表达的影响.
- 阐明不同类别的细分基因之间的调控关系.
主要方法:
- 在Drosophila胚胎中分析基因表达模式.
- 利用差距和对规则位置的突变.
- 观察fushi tarazu (ftz) 基因的空间表达.
主要成果:
- 在四个间隙位点和三个对规则位点的突变显著改变了Ftz基因的条纹表达模式.
- 另外五个对规则基因和其他基因位置对FTZ表达没有显示可检测的影响.
- 没有简单的线性监管途径被确定.
结论:
- 发怒塔拉祖 (ftz) 基因的表达取决于各种细分基因之间的复杂相互作用.
- 这些相互作用将前后轴上的位置信息整合在一起.
- 这些发现突出了控制Drosophila细分的复杂网络.
相关概念视频
02:02Cis-regulatory Sequences
9.5K
Cis-regulatory sequences are short fragments of non-coding DNA that are present on the same chromosomes as the genes that they regulate. These fragments serve as binding sites for transcriptional regulators, proteins that are responsible for controlling gene transcription and differential gene expression across cell types in eukaryotes. Cis-regulatory sequences can be close to the gene of interest or thousands of bases away in the DNA sequence; however, those sequences that are further away are...
9.5K
02:45The Ratio of X Chromosome to Autosomes
11.5K
In most organisms, sex is determined by the ratio of X and Y chromosomes. However, in some organisms, such as Drosophila and C.elegans, sex is determined by the ratio of the number of X chromosomes to the number of sets of autosomes. The Y chromosome in Drosophila is active but does not determine sex. It contains genes responsible for the production of sperms in adult flies.
Normal male Drosophila has a ratio of one X chromosome to two sets of autosomes. In contrast, normal female...
Normal male Drosophila has a ratio of one X chromosome to two sets of autosomes. In contrast, normal female...
11.5K